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Dental AI
Dental artificial intelligence (Dental AI) refers to the application of artificial intelligence (AI) and machine-learning methods to oral healthcare data. These systems can be used to find patterns or make predictions that can aid in diagnosis, treatment, patient communication, or practice management. == History and development == Research into AI for dentistry dates to the 1990s and 2000s, alongside early CAD/CAM and image-analysis work in dental radiology. Recent developments in deep learning, especially those involving computer vision, such as convolutional neural networks, trained on large image datasets, led to a rapid improvement in performance, as well as a move from prototype technology to productization suitable for use in dental chairs. Dental schools and continuing education programs started incorporating AI content in the 2020s. == Definition and core technologies == The dental AI software accomplishes this task by using various dental images and patient data. Dental images and data used by the dental AI software include bitewing and periapical X-rays, complete mouth X-rays, detailed 3D images, intraoral images, and the patient’s medical history. The dental AI software utilizes several core technologies in accomplishing its task of assisting the dentist. First, the dental AI software utilizes machine learning and deep learning using programs that can learn from examples. Such programs are referred to as convolutional neural network (CNN) and can detect cavities and identify bone changes related to gum disease. The dental AI software utilizes computer vision, which enables the AI software to identify and quantify important features in images and data, whether they are 2D images or 3D images. Natural language processing (NLP) is used for the AI software to understand written text and can automatically generate dental notes and communicate with the patient. Furthermore, the dental AI software utilizes predictive analytics to identify patients that are more prone to dental complications and can suggest the best intervals for checkups or future dental procedures. == Applications in dentistry == Reported clinical and operational applications include diagnostic assistance for caries and periodontal disease, treatment planning assistance, patient education overlays, quality assurance, curriculum assistance for dental education, and claims documentation. Systematic reviews continue to find image-based applications such as caries detection with some variability in study design and a need for prospective validation. == Academic research and clinical validation == Several peer-reviewed studies have measured the effectiveness of AI for applications such as interproximal caries detection and periodontal bone level assessment, showing improvements over unaided readings with a focus on bias within the dataset. The Dental AI Council found variability among clinicians for diagnosis and treatment planning, suggesting the use of a standard tool as an assist. == Industry adoption == Multiple vendors offer FDA-cleared chairside AI for dental imaging: Pearl — Received U.S. FDA 510(k) clearance for its real-time radiologic aid (“Second Opinion”) in 2022 (2D), with subsequent clearances including pediatric and CBCT (“Second Opinion 3D”). TIME gave “Second Opinion” a special mention on its Best Inventions of 2022 list. Overjet — FDA-cleared for bone-level quantification and detection/outline of caries and calculus (e.g., K210187), with additional clearances expanding capabilities. VideaHealth — Received an FDA 510(k) covering 30+ detections across common dental findings (K232384), including indications for patients ages 3 and up; trade coverage has described elements of this as the first pediatric dental-AI clearance. == Regulations == In the U.S., AI-enabled dental imaging software is generally reviewed via the FDA’s 510(k) pathway. The FDA maintains a public AI-Enabled Medical Devices List, which includes numerous medical-imaging AI tools (including dental). Specific dental clearances include Overjet (K210187), VideaHealth (K232384), and Pearl entries such as “Second Opinion 3D” (K243989).
Sparse PCA
Sparse principal component analysis (SPCA or sparse PCA) is a technique used in statistical analysis and, in particular, in the analysis of multivariate data sets. It extends the classic method of principal component analysis (PCA) for the reduction of dimensionality of data by introducing sparsity structures to the input variables. A particular disadvantage of ordinary PCA is that the principal components are usually linear combinations of all input variables. SPCA overcomes this disadvantage by finding components that are linear combinations of just a few input variables (SPCs). This means that some of the coefficients of the linear combinations defining the SPCs, called loadings, are equal to zero. The number of nonzero loadings is called the cardinality of the SPC. == Mathematical formulation == Consider a data matrix, X {\displaystyle X} , where each of the p {\displaystyle p} columns represent an input variable, and each of the n {\displaystyle n} rows represents an independent sample from data population. One assumes each column of X {\displaystyle X} has mean zero, otherwise one can subtract column-wise mean from each element of X {\displaystyle X} . Let Σ = 1 n − 1 X ⊤ X {\displaystyle \Sigma ={\frac {1}{n-1}}X^{\top }X} be the empirical covariance matrix of X {\displaystyle X} , which has dimension p × p {\displaystyle p\times p} . Given an integer k {\displaystyle k} with 1 ≤ k ≤ p {\displaystyle 1\leq k\leq p} , the sparse PCA problem can be formulated as maximizing the variance along a direction represented by vector v ∈ R p {\displaystyle v\in \mathbb {R} ^{p}} while constraining its cardinality: max v T Σ v subject to ‖ v ‖ 2 = 1 ‖ v ‖ 0 ≤ k . {\displaystyle {\begin{aligned}\max \quad &v^{T}\Sigma v\\{\text{subject to}}\quad &\left\Vert v\right\Vert _{2}=1\\&\left\Vert v\right\Vert _{0}\leq k.\end{aligned}}} Eq. 1 The first constraint specifies that v is a unit vector. In the second constraint, ‖ v ‖ 0 {\displaystyle \left\Vert v\right\Vert _{0}} represents the ℓ 0 {\displaystyle \ell _{0}} pseudo-norm of v, which is defined as the number of its non-zero components. So the second constraint specifies that the number of non-zero components in v is less than or equal to k, which is typically an integer that is much smaller than dimension p. The optimal value of Eq. 1 is known as the k-sparse largest eigenvalue. If one takes k=p, the problem reduces to the ordinary PCA, and the optimal value becomes the largest eigenvalue of covariance matrix Σ. After finding the optimal solution v, one deflates Σ to obtain a new matrix Σ 1 = Σ − ( v T Σ v ) v v T , {\displaystyle \Sigma _{1}=\Sigma -(v^{T}\Sigma v)vv^{T},} and iterate this process to obtain further principal components. However, unlike PCA, sparse PCA cannot guarantee that different principal components are orthogonal. In order to achieve orthogonality, additional constraints must be enforced. The following equivalent definition is in matrix form. Let V {\displaystyle V} be a p×p symmetric matrix, one can rewrite the sparse PCA problem as max T r ( Σ V ) subject to T r ( V ) = 1 ‖ V ‖ 0 ≤ k 2 R a n k ( V ) = 1 , V ⪰ 0. {\displaystyle {\begin{aligned}\max \quad &Tr(\Sigma V)\\{\text{subject to}}\quad &Tr(V)=1\\&\Vert V\Vert _{0}\leq k^{2}\\&Rank(V)=1,V\succeq 0.\end{aligned}}} Eq. 2 Tr is the matrix trace, and ‖ V ‖ 0 {\displaystyle \Vert V\Vert _{0}} represents the non-zero elements in matrix V. The last line specifies that V has matrix rank one and is positive semidefinite. The last line means that one has V = v v T {\displaystyle V=vv^{T}} , so Eq. 2 is equivalent to Eq. 1. Moreover, the rank constraint in this formulation is actually redundant, and therefore sparse PCA can be cast as the following mixed-integer semidefinite program max T r ( Σ V ) subject to T r ( V ) = 1 | V i , i | ≤ z i , ∀ i ∈ { 1 , . . . , p } , | V i , j | ≤ 1 2 z i , ∀ i , j ∈ { 1 , . . . , p } : i ≠ j , V ⪰ 0 , z ∈ { 0 , 1 } p , ∑ i z i ≤ k {\displaystyle {\begin{aligned}\max \quad &Tr(\Sigma V)\\{\text{subject to}}\quad &Tr(V)=1\\&\vert V_{i,i}\vert \leq z_{i},\forall i\in \{1,...,p\},\vert V_{i,j}\vert \leq {\frac {1}{2}}z_{i},\forall i,j\in \{1,...,p\}:i\neq j,\\&V\succeq 0,z\in \{0,1\}^{p},\sum _{i}z_{i}\leq k\end{aligned}}} Eq. 3 Because of the cardinality constraint, the maximization problem is hard to solve exactly, especially when dimension p is high. In fact, the sparse PCA problem in Eq. 1 is NP-hard in the strong sense. == Computational considerations == As most sparse problems, variable selection in SPCA is a computationally intractable non-convex NP-hard problem, therefore greedy sub-optimal algorithms are often employed to find solutions. Note also that SPCA introduces hyperparameters quantifying in what capacity large parameter values are penalized. These might need tuning to achieve satisfactory performance, thereby adding to the total computational cost. == Algorithms for SPCA == Several alternative approaches (of Eq. 1) have been proposed, including a regression framework, a penalized matrix decomposition framework, a convex relaxation/semidefinite programming framework, a generalized power method framework an alternating maximization framework forward-backward greedy search and exact methods using branch-and-bound techniques, a certifiably optimal branch-and-bound approach Bayesian formulation framework. A certifiably optimal mixed-integer semidefinite branch-and-cut approach The methodological and theoretical developments of Sparse PCA as well as its applications in scientific studies are recently reviewed in a survey paper. === Notes on Semidefinite Programming Relaxation === It has been proposed that sparse PCA can be approximated by semidefinite programming (SDP). If one drops the rank constraint and relaxes the cardinality constraint by a 1-norm convex constraint, one gets a semidefinite programming relaxation, which can be solved efficiently in polynomial time: max T r ( Σ V ) subject to T r ( V ) = 1 1 T | V | 1 ≤ k V ⪰ 0. {\displaystyle {\begin{aligned}\max \quad &Tr(\Sigma V)\\{\text{subject to}}\quad &Tr(V)=1\\&\mathbf {1} ^{T}|V|\mathbf {1} \leq k\\&V\succeq 0.\end{aligned}}} Eq. 3 In the second constraint, 1 {\displaystyle \mathbf {1} } is a p×1 vector of ones, and |V| is the matrix whose elements are the absolute values of the elements of V. The optimal solution V {\displaystyle V} to the relaxed problem Eq. 3 is not guaranteed to have rank one. In that case, V {\displaystyle V} can be truncated to retain only the dominant eigenvector. While the semidefinite program does not scale beyond n=300 covariates, it has been shown that a second-order cone relaxation of the semidefinite relaxation is almost as tight and successfully solves problems with n=1000s of covariates == Applications == === Financial Data Analysis === Suppose ordinary PCA is applied to a dataset where each input variable represents a different asset, it may generate principal components that are weighted combination of all the assets. In contrast, sparse PCA would produce principal components that are weighted combination of only a few input assets, so one can easily interpret its meaning. Furthermore, if one uses a trading strategy based on these principal components, fewer assets imply less transaction costs. === Biology === Consider a dataset where each input variable corresponds to a specific gene. Sparse PCA can produce a principal component that involves only a few genes, so researchers can focus on these specific genes for further analysis. === High-dimensional Hypothesis Testing === Contemporary datasets often have the number of input variables ( p {\displaystyle p} ) comparable with or even much larger than the number of samples ( n {\displaystyle n} ). It has been shown that if p / n {\displaystyle p/n} does not converge to zero, the classical PCA is not consistent. In other words, if we let k = p {\displaystyle k=p} in Eq. 1, then the optimal value does not converge to the largest eigenvalue of data population when the sample size n → ∞ {\displaystyle n\rightarrow \infty } , and the optimal solution does not converge to the direction of maximum variance. But sparse PCA can retain consistency even if p ≫ n . {\displaystyle p\gg n.} The k-sparse largest eigenvalue (the optimal value of Eq. 1) can be used to discriminate an isometric model, where every direction has the same variance, from a spiked covariance model in high-dimensional setting. Consider a hypothesis test where the null hypothesis specifies that data X {\displaystyle X} are generated from a multivariate normal distribution with mean 0 and covariance equal to an identity matrix, and the alternative hypothesis specifies that data X {\displaystyle X} is generated from a spiked model with signal strength θ {\displaystyle \theta } : H 0 : X ∼ N ( 0 , I p ) , H 1 : X ∼ N ( 0 , I p + θ v v T ) , {\displaystyle H_{0}:X\sim N(0,I_{p}),\quad H_{1}:X\sim N(0,I_{p}+\theta vv^{T}),} where v ∈ R p {\displaystyle v\in \mathbb {R} ^{p}
Cartesian genetic programming
Cartesian genetic programming is a form of genetic programming that uses a graph representation to encode computer programs. It grew from a method of evolving digital circuits developed by Julian F. Miller and Peter Thomson in 1997. The term ‘Cartesian genetic programming’ first appeared in 1999 and was proposed as a general form of genetic programming in 2000. It is called ‘Cartesian’ because it represents a program using a two-dimensional grid of nodes. Miller's keynote explains how CGP works. He edited a book entitled Cartesian Genetic Programming, published in 2011 by Springer. The open source project dCGP implements a differentiable version of CGP developed at the European Space Agency by Dario Izzo, Francesco Biscani and Alessio Mereta able to approach symbolic regression tasks, to find solution to differential equations, find prime integrals of dynamical systems, represent variable topology artificial neural networks and more.
Amazon Rekognition
Amazon Rekognition is a cloud-based software as a service (SaaS) computer vision platform that was launched in 2016. It has been sold to, and used by, a number of United States government agencies, including U.S. Immigration and Customs Enforcement (ICE) and Orlando, Florida police, as well as private entities. == Capabilities == Rekognition provides a number of computer vision capabilities, which can be divided into two categories: Algorithms that are pre-trained on data collected by Amazon or its partners, and algorithms that a user can train on a custom dataset. As of July 2019, Rekognition provides the following computer vision capabilities. === Pre-trained algorithms === Celebrity recognition in images Facial attribute detection in images, including gender, age range, emotions (e.g. happy, calm, disgusted), whether the face has a beard or mustache, whether the face has eyeglasses or sunglasses, whether the eyes are open, whether the mouth is open, whether the person is smiling, and the location of several markers such as the pupils and jaw line. People Pathing enables tracking of people through a video. An advertised use-case of this capability is to track sports players for post-game analysis. Text detection and classification in images Unsafe visual content detection === Algorithms that a user can train on a custom dataset === SearchFaces enables users to import a database of images with pre-labeled faces, to train a machine learning model on this database, and to expose the model as a cloud service with an API. Then, the user can post new images to the API and receive information about the faces in the image. The API can be used to expose a number of capabilities, including identifying faces of known people, comparing faces, and finding similar faces in a database. Face-based user verification == History and use == === 2017 === In late 2017, the Washington County, Oregon Sheriff's Office began using Rekognition to identify suspects' faces. Rekognition was marketed as a general-purpose computer vision tool, and an engineer working for Washington County decided to use the tool for facial analysis of suspects. Rekognition was offered to the department for free, and Washington County became the first US law enforcement agency known to use Rekognition. In 2018, the agency logged over 1,000 facial searches. The county, according to the Washington Post, by 2019 was paying about $7 a month for all of its searches. The relationship was unknown to the public until May 2018. In 2018, Rekognition was also used to help identify celebrities during a royal wedding telecast. === 2018 === In April 2018, it was reported that FamilySearch was using Rekognition to enable their users to "see which of their ancestors they most resemble based on family photographs". In early 2018, the FBI also began using it as a pilot program for analyzing video surveillance. In May 2018, it was reported by the ACLU that Orlando, Florida was running a pilot using Rekognition for facial analysis in law enforcement, with that pilot ending in July 2019. After the report, on June 22, 2018, Gizmodo reported that Amazon workers had written a letter to CEO Jeff Bezos requesting he cease selling Rekognition to US law enforcement, particularly ICE and Homeland Security. A letter was also sent to Bezos by the ACLU. On June 26, 2018, it was reported that the Orlando police force had ceased using Rekognition after their trial contract expired, reserving the right to use it in the future. The Orlando Police Department said that they had "never gotten to the point to test images" due to old infrastructure and low bandwidth. In July 2018, the ACLU released a test showing that Rekognition had falsely matched 28 members of Congress with mugshot photos, particularly Congresspeople of color. 25 House members afterwards sent a letter to Bezos, expressing concern about Rekognition. Amazon responded saying the Rekognition test had generated 80 percent confidence, while it recommended law enforcement only use matches rated at 99 percent confidence. The Washington Post states that Oregon instead has officers pick a "best of five" result, instead of adhering to the recommendation. In September 2018, it was reported that Mapillary was using Rekognition to read the text on parking signs (e.g. no stopping, no parking, or specific parking hours) in cities. In October 2018, it was reported that Amazon had earlier that year pitched Rekognition to U.S. Immigration and Customs Enforcement agency. Amazon defended government use of Rekognition. On December 1, 2018, it was reported that 8 Democratic lawmakers had said in a letter that Amazon had "failed to provide sufficient answers" about Rekognition, writing that they had "serious concerns that this type of product has significant accuracy issues, places disproportionate burdens on communities of color, and could stifle Americans' willingness to exercise their First Amendment rights in public." === 2019 === In January 2019, MIT researchers published a peer-reviewed study asserting that Rekognition had more difficulty in identifying dark-skinned females than competitors such as IBM and Microsoft. In the study, Rekognition misidentified darker-skinned women as men 31% of the time, but made no mistakes for light-skinned men. Amazon called the report "misinterpreted results" of the research with an improper "default confidence threshold." In January 2019, Amazon's shareholders "urged Amazon to stop selling Rekognition software to law enforcement agencies." Amazon in response defended its use of Rekognition, but supported new federal oversight and guidelines to "make sure facial recognition technology cannot be used to discriminate." In February 2019, it was reported that Amazon was collaborating with the National Institute of Standards and Technology (NIST) on developing standardized tests to improve accuracy and remove bias with facial recognition. In March 2019, an open letter regarding Rekognition was sent by a group of prominent AI researchers to Amazon, criticizing its sale to law enforcement with around 50 signatures. In April 2019, Amazon was told by the Securities and Exchange Commission that they had to vote on two shareholder proposals seeking to limit Rekognition. Amazon argued that the proposals were an "insignificant public policy issue for the Company" not related to Amazon's ordinary business, but their appeal was denied. The vote was set for May. The first proposal was tabled by shareholders. On May 24, 2019, 2.4% of shareholders voted to stop selling Rekognition to government agencies, while a second proposal calling for a study into Rekognition and civil rights had 27.5% support. In August 2019, the ACLU again used Rekognition on members of government, with 26 of 120 lawmakers in California flagged as matches to mugshots. Amazon stated the ACLU was "misusing" the software in the tests, by not dismissing results that did not meet Amazon's recommended accuracy threshold of 99%. By August 2019, there had been protests against ICE's use of Rekognition to surveil immigrants. In March 2019, Amazon announced a Rekognition update that would improve emotional detection, and in August 2019, "fear" was added to emotions that Rekognition could detect. === 2020 === In June 2020, Amazon announced it was implementing a one-year moratorium on police use of Rekognition, in response to the George Floyd protests. === 2024 === The Department of Justice disclosed that the FBI is initiating the use of Amazon Rekognition. The DOJ's AI inventory revealed the FBI's "Project Tyr" aims to customize Rekognition to identify nudity, weapons, explosives, and other information from lawfully acquired media. === 2025 === In late 2025, the New York Times reported that scientist, Dr. Jürgen Matthäus, retired from as the head of research at the U.S. Holocaust Memorial Museum in Washington, D.C., used Amazon Rekognition to identify the shooter in the Holocaust photograph known as The Last Jew in Vinnitsa "with more than 99 percent certainty" — as Jakobus Onnen (1906–1943), a teacher from Tichelwarf near Weener in East Frisia who had been a member of the SS since 1934 and was later killed in action near Zhitomir in 1943. The photographer and victim remain unidentified. == Controversy regarding facial analysis == === Racial and gender bias === In 2018, MIT researchers Joy Buolamwini and Timnit Gebru published a study called Gender Shades. In this study, a set of images was collected, and faces in the images were labeled with face position, gender, and skin tone information. The images were run through SaaS facial recognition platforms from Face++, IBM, and Microsoft. In all three of these platforms, the classifiers performed best on male faces (with error rates on female faces being 8.1% to 20.6% higher than error rates on male faces), and they performed worst on dark female faces (with error rates ranging from 20.8% to 30.4%). The authors hypothesized that this discr
Common data model
A common data model (CDM) can refer to any standardised data model which allows for data and information exchange between different applications and data sources. Common data models aim to standardise logical infrastructure so that related applications can "operate on and share the same data", and can be seen as a way to "organize data from many sources that are in different formats into a standard structure". A common data model has been described as one of the components of a "strong information system". A standardised common data model has also been described as a typical component of a well designed agile application besides a common communication protocol. Providing a single common data model within an organisation is one of the typical tasks of a data warehouse. == Examples of common data models == === Border crossings === X-trans.eu was a cross-border pilot project between the Free State of Bavaria (Germany) and Upper Austria with the aim of developing a faster procedure for the application and approval of cross-border large-capacity transports. The portal was based on a common data model that contained all the information required for approval. === Climate data === The Climate Data Store Common Data Model is a common data model set up by the Copernicus Climate Change Service for harmonising essential climate variables from different sources and data providers. === General information technology === Within service-oriented architecture, S-RAMP is a specification released by HP, IBM, Software AG, TIBCO, and Red Hat which defines a common data model for SOA repositories as well as an interaction protocol to facilitate the use of common tooling and sharing of data. Content Management Interoperability Services (CMIS) is an open standard for inter-operation of different content management systems over the internet, and provides a common data model for typed files and folders used with version control. The NetCDF software libraries for array-oriented scientific data implements a common data model called the NetCDF Java common data model, which consists of three layers built on top of each other to add successively richer semantics. === Health === Within genomic and medical data, the Observational Medical Outcomes Partnership (OMOP) research program established under the U.S. National Institutes of Health has created a common data model for claims and electronic health records which can accommodate data from different sources around the world. PCORnet, which was developed by the Patient-Centered Outcomes Research Institute, is another common data model for health data including electronic health records and patient claims. The Sentinel Common Data Model was initially started as Mini-Sentinel in 2008. It is used by the Sentinel Initiative of the USA's Food and Drug Administration. The Generalized Data Model was first published in 2019. It was designed to be a stand-alone data model as well as to allow for further transformation into other data models (e.g., OMOP, PCORNet, Sentinel). It has a hierarchical structure to flexibly capture relationships among data elements. The JANUS clinical trial data repository also provides a common data model which is based on the SDTM standard to represent clinical data submitted to regulatory agencies, such as tabulation datasets, patient profiles, listings, etc. === Logistics === SX000i is a specification developed jointly by the Aerospace and Defence Industries Association of Europe (ASD) and the American Aerospace Industries Association (AIA) to provide information, guidance and instructions to ensure compatibility and the commonality. The associated SX002D specification contains a common data model. === Microsoft Common Data Model === The Microsoft Common Data Model is a collection of many standardised extensible data schemas with entities, attributes, semantic metadata, and relationships, which represent commonly used concepts and activities in various businesses areas. It is maintained by Microsoft and its partners, and is published on GitHub. Microsoft's Common Data Model is used amongst others in Microsoft Dataverse and with various Microsoft Power Platform and Microsoft Dynamics 365 services. === Rail transport === RailTopoModel is a common data model for the railway sector. === Other === There are many more examples of various common data models for different uses published by different sources.
Multimodal learning
Multimodal learning is a type of deep learning that integrates and processes multiple types of data, referred to as modalities, such as text, audio, images, or video. This integration allows for a more holistic understanding of complex data, improving model performance in tasks like visual question answering, cross-modal retrieval, text-to-image generation, aesthetic ranking, and image captioning. Multimodal learning was proposed in 2011 at the beginning of the deep learning period. Large multimodal models, such as Google Gemini and GPT-4o, have become increasingly popular since 2023, enabling increased versatility and a broader understanding of real-world phenomena. == Motivation == Data usually comes with different modalities which carry different information. For example, it is very common to caption an image to convey the information not presented in the image itself. Similarly, sometimes it is more straightforward to use an image to describe information which may not be obvious from text. As a result, if different words appear in similar images, then these words likely describe the same thing. Conversely, if a word is used to describe seemingly dissimilar images, then these images may represent the same object. Thus, in cases dealing with multi-modal data, it is important to use a model which is able to jointly represent the information such that the model can capture the combined information from different modalities. == Multimodal transformers == Models such as CLIP (Contrastive Language–Image Pretraining) learn joint representations of images and text by optimizing contrastive objectives, allowing the model to match images with their corresponding textual descriptions. == Multimodal deep Boltzmann machines == A Boltzmann machine is a type of stochastic neural network invented by Geoffrey Hinton and Terry Sejnowski in 1985. Boltzmann machines can be seen as the stochastic, generative counterpart of Hopfield nets. They are named after the Boltzmann distribution in statistical mechanics. The units in Boltzmann machines are divided into two groups: visible units and hidden units. Each unit is like a neuron with a binary output that represents whether it is activated or not. General Boltzmann machines allow connection between any units. However, learning is impractical using general Boltzmann Machines because the computational time is exponential to the size of the machine. A more efficient architecture is called restricted Boltzmann machine where connection is only allowed between hidden unit and visible unit, which is described in the next section. Multimodal deep Boltzmann machines can process and learn from different types of information, such as images and text, simultaneously. This can notably be done by having a separate deep Boltzmann machine for each modality, for example one for images and one for text, joined at an additional top hidden layer. == Applications == Multimodal machine learning has numerous applications across various domains: Cross-modal retrieval: cross-modal retrieval allows users to search for data across different modalities (e.g., retrieving images based on text descriptions), improving multimedia search engines and content recommendation systems. Classification and missing data retrieval: multimodal Deep Boltzmann Machines outperform traditional models like support vector machines and latent Dirichlet allocation in classification tasks and can predict missing data in multimodal datasets, such as images and text. Healthcare diagnostics: multimodal models integrate medical imaging, genomic data, and patient records to improve diagnostic accuracy and early disease detection, especially in cancer screening. Content generation: models like DALL·E generate images from textual descriptions, benefiting creative industries, while cross-modal retrieval enables dynamic multimedia searches. Robotics and human-computer interaction: multimodal learning improves interaction in robotics and AI by integrating sensory inputs like speech, vision, and touch, aiding autonomous systems and human-computer interaction. Emotion recognition: combining visual, audio, and text data, multimodal systems enhance sentiment analysis and emotion recognition, applied in customer service, social media, and marketing.